Hydrochloric Acid → HCID 86639691, compound

Participants

Reaction Steps

N-(3-(benzyloxy)-5-(pent-1-enyl)pyridin-2-yl)-4-methylthiazol-2-amine (360 mg, 0.98 mmol) and 4-methylbenzenesulfonohydrazide (733 mg, 3.94 mmol) were reacted according to Example 93 to afford the title compound (150.2 mg, 37.7% yield) as a white solid after HCl salt formation. 1H NMR (DMSO-d6) 11.24 (bs, 1H), 7.83 (d, 1H), 7.61 (d, 2H), 7.56 (d, 2H), 7.44-7.32 (m, 3H), 6.87 (s, 1H), 5.34 (s, 2H), 2.57 (t, 2H), 2.33 (s, 3H), 1.57 (m, 2H), 1.35-1.18 (m, 4H), 0.85 (t, 3H). Mass spectrum (apci) m/z=368.1 (M+H-HCl).

Provenance & Evidence