HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 4-(2-aminoethyl)-N-(3-(benzyloxy)pyridin-2-yl)thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(2-(2-(3-(Benzyloxy)pyridin-2-ylamino)thiazol-4-yl)ethyl)isoindoline-1,3-dione | HCID 16662079 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-aminoethyl)-N-(3-(benzyloxy)pyridin-2-yl)thiazol-2-amine | HCID 86639704 | — |
Reaction Steps
A mixture of 2-(2-(2-(3-(benzyloxy)pyridin-2-ylamino)thiazol-4-yl)ethyl)isoindoline-1,3-dione (13.8 g, 30.2 mmol) and hydrazine hydrate (3.03 g, 60.5 mmol) in methanol (150 mL) was heated at reflux for 3 hours, then cooled and concentrated. The crude residue was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933077B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-67a7eac0111542aea895af2fc5093e86 |
| Source note | uspto-grants-2015_01 |