Phenylacetylene → 2-Methyl-6-phenylethynyl-pyrazolo[1,5-a]pyrimidine

HRID 1426186Notes

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=2)[CH:7]=1.[C:12]1([C:18]#[CH:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:11][C:9]1[CH:10]=[C:5]2[N:4]=[CH:3][C:2]([C:19]#[C:18][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:7][N:6]2[N:8]=1

Participants

Reactant 2

HCID 10821Phenylacetylene

HCID 159800416-Bromo-2-methylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 532470722-Methyl-6-phenylethynyl-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, white solid, MS: m/e=234.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine and phenylacetylene.

Sources & evidence

ORD record: ord-050ea7a45cd045709bd130873f70a17d
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933094B2

Reaction notes

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