1-Ethynyl-3-fluorobenzene → 2-tert-Butyl-6-(3-fluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

HRID 1426196Notes

Reaction equation

HRID 1426196 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=2)[CH:7]=1.[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=1)#[CH:16]>>[C:11]([C:9]1[CH:10]=[C:5]2[N:4]=[CH:3][C:2]([C:16]#[C:15][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[CH:7][N:6]2[N:8]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzeneHCID 583166976-Bromo-2-tert-butylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 532471982-tert-Butyl-6-(3-fluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, light yellow solid, MS: m/e=294.2 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-tert-butyl-pyrazolo[1,5-a]pyrimidine (example 9, step 1) and 1-ethynyl-3-fluoro-benzene.

Sources & evidence

ORD record
ord-6e6a33d2e1ca4c4d9bee16a117eeb2c5
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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