3-Methylphenylacetylene → 2-tert-Butyl-6-m-tolylethynyl-pyrazolo[1,5-a]pyrimidine

HRID 1426201노트

반응식

HRID 1426201 반응식
Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=2)[CH:7]=1.[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[CH:18]=1)#[CH:16]>>[C:11]([C:9]1[CH:10]=[C:5]2[N:4]=[CH:3][C:2]([C:16]#[C:15][C:17]3[CH:18]=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)=[CH:7][N:6]2[N:8]=1)([CH3:14])([CH3:13])[CH3:12]

참가 물질

3

반응물 2

HCID 1366003-MethylphenylacetyleneHCID 583166976-Bromo-2-tert-butylpyrazolo[1,5-a]pyrimidine

생성물 1

HCID 532472022-tert-Butyl-6-m-tolylethynyl-pyrazolo[1,5-a]pyrimidine

실험 절차

The title compound, yellow solid, MS: m/e=290.2 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-tert-butyl-pyrazolo[1,5-a]pyrimidine (example 9, step 1) and 1-ethynyl-3-methylbenzene.

출처 및 근거

ORD 기록
ord-c9ad32c398d14740892dfd68144cf38a
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933094B2

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