2-Pyridinamine, 5-iodo- → 5-(2-tert-Butyl-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-pyridin-2-ylamine

HRID 1426210Notes

Reaction equation

HRID 1426210 reaction equation
[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].I[C:17]1[CH:18]=[CH:19][C:20]([NH2:23])=[N:21][CH:22]=1>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:17]3[CH:18]=[CH:19][C:20]([NH2:23])=[N:21][CH:22]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 885792-Pyridinamine, 5-iodo-HCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 532473295-(2-tert-Butyl-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-pyridin-2-ylamine

Procedure

The title compound, off white solid, MS: m/e=292.1 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 5-iodopyridin-2-amine.

Sources & evidence

ORD record
ord-1cb737a1345743c6af303c11a55794cc
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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