Phenylacetylene → 5-Phenylethynyl-pyridin-2-ylamine

HRID 1426220Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][N:3]=1.[C:9]1([C:15]#[CH:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([C:15]#[C:16][C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[N:3][CH:4]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 10821Phenylacetylene

HCID 885792-Pyridinamine, 5-iodo-

Product 1

HCID 468541905-Phenylethynyl-pyridin-2-ylamine

Procedure

The title compound, light yellow solid, MS: m/e=195.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-amino-5-iodopyridine and phenylacetylene.

Sources & evidence

ORD record: ord-58c1e378a7ad4c599d78fdca56dace8b
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933094B2

Reaction notes

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