1,4-Difluoro-2-iodobenzene → 2-tert-Butyl-6-(2,5-difluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

HRID 1426226Notes

Reaction equation

HRID 1426226 reaction equation
[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=1I>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:21]3[CH:22]=[C:17]([F:16])[CH:18]=[CH:19][C:20]=3[F:23])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2230841,4-Difluoro-2-iodobenzeneHCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 532474552-tert-Butyl-6-(2,5-difluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, a white solid, MS: m/e=312.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 1,4-difluoro-2-iodobenzene.

Sources & evidence

ORD record
ord-b498815e5d914f19bdcb57cb35ac8df1
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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