1-Chloro-3-ethynylbenzene → HCID 53245753, compound

HRID 1426252Notes

Reaction equation

HRID 1426252 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)[N:10]=2)[CH:7]=1.[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)#[CH:18]>>[Cl:25][C:21]1[CH:20]=[C:19]([C:17]#[C:18][C:2]2[CH:3]=[N:4][C:5]3[N:6]([N:8]=[C:9]([N:11]4[CH2:16][CH2:15][O:14][CH2:13][CH2:12]4)[N:10]=3)[CH:7]=2)[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 1230861-Chloro-3-ethynylbenzeneHCID 58316703HCID 58316703, compound

Product 1

HCID 53245753HCID 53245753, compound

Procedure

The title compound, a light brown solid, MS: m/e=340.0/342.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidine (example 47, step 1) and ethynyl-3-chlorobenzene.

Sources & evidence

ORD record
ord-2fb99d8a3c3046909988b89c0236928e
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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