Lithium borohydride → HCID 69672941, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[3-bromo-5-(methoxycarbonyl)phenoxy]piperidine-1-carboxylate (520 mg, 1.2 mmol) in THF (10 mL) was added lithium tetrahydroborate (27.3 mg, 1.26 mmol). The resulting solution was stirred at room temperature for 1 hour. The reaction was quenched with 1N HCl. The organic solution was washed with brine, dried over Na2SC4, filtered and concentrated. The crude was purified by flash chromatography on a silica gel column to give the desired product. LCMS (M+Na)+: 408.1, 410.1.

Provenance & Evidence