Ethylamine → tert-Butyl 4-{[6-[(ethylamino)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

HRID 1426357Notes

Reaction equation

HRID 1426357 reaction equation
[CH:1]([C:3]1[N:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:6]=[C:5]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]2)[CH:4]=1)=O.[CH2:27]([NH2:29])[CH3:28]>>[CH2:27]([NH:29][CH2:1][C:3]1[N:8]=[C:7]([C:9]([F:12])([F:10])[F:11])[N:6]=[C:5]([O:13][CH:14]2[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:25])([CH3:24])[CH3:26])=[O:21])[CH2:18][CH2:19]2)[CH:4]=1)[CH3:28]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 86666511tert-Butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

Product 1

HCID 67954294tert-Butyl 4-{[6-[(ethylamino)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

Procedure

This compound was prepared according to the method of Example 41, Step 2 using tert-butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate and ethylamine as starting materials. LCMS (M+H)+: 405.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e72b234a79cf4702ba755dbc7dbe75cd
Source dataset
uspto-grants-2015_01
Patent number
US08933085B2

Reaction notes

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