Dichloromethane → HCID 71652161, compound

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Reaction Steps

To tert-butyl (3S,4R)-3-[(1,3-dihydro-2-benzofuran-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylate (4.1 g, 9.6 mmol) described in Production Example 1-4 was added a mixed solution of trifluoroacetic acid (5 mL) and dichloromethane (30 mL) under ice cooling, followed by stirring at room temperature for 90 minutes. Toluene (30 mL) was added to the reaction mixture, and the solvent was distilled away under reduced pressure. The residue was purified by NH silica gel column chromatography (methanol:ethyl acetate=1:20) to give the title compound (2.7 g, 84% yield).

Provenance & Evidence