Hydrochloric Acid → HCID 86694558, compound

Participants

Reaction Steps

To the solution of methyl 4-{(1E,5R,6S)-6-{[tert-butyl(dimethyl)silyl]oxy}-5-[(tert-butylsulfinyl)amino]-7-phenoxyhept-1-en-1-yl}benzoate from step A (1.05 g, 1.74 mM) in 10 ml of methylene chloride was added 1 ml of HCl (4M, in dioxane) and the resulting mixture stirred at RT for 15 min. Removal of the volatiles under reduced pressure afforded 0.93 g of the title compound (as HCl salt) which was directly used for the next step. LC-MS: m/z (ES) 470.41 (M+1).

Provenance & Evidence