HCID 86694562, compound → HCID 86694561, compound

Participants

Reaction Steps

To a solution of methyl 4-[3-((3R,4S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-phenoxypentyl)oxiran-2-yl]benzoate from step D (410 mg, 0.7 mM) in 15 ml of methanol was added 100 mg of palladium on carbon (10%) and the suspension was set under 40 PSI of hydrogen gas and shaken for 2 h on the Parr shaker. The catalyst was filtered and the filtrate concentrated under reduced pressure to afford 378 mg of the title compound which was directly used for next step. LC-MS: m/z (ES) 488.21 (M-Boc+1).

Provenance & Evidence