HCID 86694563, compound → HCID 86694564, compound

HRID 1426393Notes

Reaction equation

HRID 1426393 reaction equation
C(OC([NH:8][C@@H:9]([C@H:25]([O:34][Si:35]([C:38]([CH3:41])([CH3:40])[CH3:39])([CH3:37])[CH3:36])[CH2:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:10][CH2:11][C:12](=O)[CH2:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=1)=O)(C)(C)C>C(Cl)Cl>[Si:35]([O:34][C@@H:25]([C@H:9]1[CH2:10][CH2:11][C:12]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:22][CH:23]=2)=[N:8]1)[CH2:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:38]([CH3:41])([CH3:39])[CH3:40])([CH3:37])[CH3:36]

Participants

3

Reactant 1

HCID 86694563HCID 86694563, compound

Product 1

HCID 86694564HCID 86694564, compoundYield 124.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl 4-{(5R,6S)-5-[(tert-butoxycarbonyl)amino]-6-{[tert-butyl(dimethyl)silyl]oxy}-2-oxo-7-phenoxyheptyl}benzoate from step F (130 mg, 0.22 mM) in 5 ml of methylene chloride was treated with 0.5 ml of TEA at RT for 20 min. The volitiles were removed via concentrating under reduced pressure to afford 129 mg of the title compound. This material was directly used for next step. LC-MS: m/z (ES) 468.17 (M+1).

Workup

  1. customThe volitiles were removed
  2. concentrationvia concentrating under reduced pressure

Sources & evidence

ORD record
ord-bba8eacb56304e1d9bbd82486b115fa6
Source dataset
uspto-grants-2015_01
Patent number
US08933102B2

Reaction notes

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