反应详情

To a solution of 5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde (200 mg) in tetrahydrofuran (20 mL) was added sodium hydride (60% in oil, 64 mg) at room temperature and the mixture was stirred for 10 min. 15-Crown-5 (348 mg) was added dropwise, and the mixture was stirred for 5 min. 1,3-Benzodioxole-5-sulfonyl chloride (250 mg) was added, and the mixture was further stirred for 30 min. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=3:2→2:3) and crystallized from diethyl ether to give the title compound as colorless crystals (yield 250 mg, 64%).

1. stirringthe mixture was stirred for 5 min
2. stirringthe mixture was further stirred for 30 min
3. extractionextracted with ethyl acetate
4. washThe extract was washed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=3:2→2:3)
8. customcrystallized from diethyl ether