HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 59826894, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(2-Fluoro-3-pyridinyl)-1-propanone | HCID 59826871 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 59826894 | HCID 59826894 | — |
Reaction Steps
To a mixture of 1-(2-fluoropyridin-3-yl)propan-1-one (12.9 g) and 25% solution (70 mL) of hydrogen bromide in acetic acid was added dropwise bromine (4.4 mL), and the obtained mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure to give the title compound as a red-brown oil (yield 29.6 g, quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933105B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7ea1891125904c788398aec76e096f5d |
| Source note | uspto-grants-2015_01 |