Triethylamine → HCID 67395699, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-chloro-5-(2-fluoropyridin-3-yl)-4-methyl-1H-pyrrole-3-carboxylate (10.0 g) and triethylamine (5.5 mL) in ethanol (250 mL) was added 10% palladium carbon (50% containing water, 1.43 g), and the mixture was stirred under a hydrogen atmosphere at 60° C. for 3 hr. After cooling, the reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound as colorless crystals (yield 7.93 g, 90%).

Provenance & Evidence