Dimethylformamide → HCID 67396653, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate (7.24 g), zinc cyanide (3.55 g) and tetrakis(triphenylphosphine)palladium (0) (3.56 g) in N,N-dimethylformamide (80 mL) was stirred at 120° C. for 20 hr. The reaction mixture was cooled to room temperature, and insoluble materials were filtered off. Water was added to the filtrate, and the mixture was extracted with ethyl acetate. The extract washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=2:1) to give a mixture of tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate and the title compound. A suspension of the obtained mixture, zinc cyanide (3.56 g) and tetrakis(triphenylphosphine)palladium (0) (3.38 g) in N,N-dimethylformamide (80 mL) was stirred at 120° C. for 12 hr. The reaction mixture was cooled to room temperature, and insoluble materials were filtered off. Water was added to the filtrate, and the mixture was extracted with ethyl acetate. The extract washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=2:1) to give the title compound as a yellow oil (yield 5.84 g, 82%).

Provenance & Evidence