Tetrahydrofuran → HCID 67397020, compound

Participants

Reaction Steps

To a mixture of tert-butyl {[5-(2-cyanopyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate (5.43 g), tetrahydrofuran (50 mL), and methanol (13 mL) was added a 8 mol/L aqueous sodium hydroxide solution (2 mL) at 0° C., and the mixture was stirred at the same temperature for 30 min. The reaction mixture was concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The extract washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: hexane:ethyl acetate=1:1), and further by silica gel column chromatography (eluent: hexane:ethyl acetate=1:1) to give the title compound as a yellow oil (yield 2.18 g, 57%).

Provenance & Evidence