Hydrogen chloride-ethyl acetate → HCID 67398196, compound

HRID 1426779Notes

Reaction equation

HRID 1426779 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[C:17]([F:22])=[N:18][CH:19]=[CH:20][CH:21]=3)=[CH:14][C:13]([CH2:23][N:24](C)[C:25](=O)OC(C)(C)C)=[CH:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.C(OCC)(=O)C.[ClH:39]>C(O)C>[ClH:39].[F:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[C:17]([F:22])=[N:18][CH:19]=[CH:20][CH:21]=3)=[CH:14][C:13]([CH2:23][NH:24][CH3:25])=[CH:12]2)(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67396631HCID 67396631, compound

Product 1

HCID 67398196HCID 67398196, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl ({1-[(3-fluorophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}methyl)methylcarbamate (194 mg) in ethanol (2 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound (yield 90 mg, 54%).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-5da1b9a0da0a4cfa9456146328a3eaeb
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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