Hydrogen chloride-ethyl acetate → HCID 67396772, compound

HRID 1426783Notes

Reaction equation

HRID 1426783 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([S:10]([N:13]2[C:17]([C:18]3[C:19]([F:24])=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:16][C:15]([CH2:25][N:26](C)[C:27](=O)OC(C)(C)C)=[CH:14]2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].C(OCC)(=O)C.[ClH:41]>C(O)C>[ClH:41].[F:24][C:19]1[C:18]([C:17]2[N:13]([S:10]([C:6]3[CH:5]=[C:4]([C:1](=[O:3])[CH3:2])[CH:9]=[CH:8][CH:7]=3)(=[O:12])=[O:11])[CH:14]=[C:15]([CH2:25][NH:26][CH3:27])[CH:16]=2)=[CH:23][CH:22]=[CH:21][N:20]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67396230HCID 67396230, compound

Product 1

HCID 67396772HCID 67396772, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl ({1-[(3-acetylphenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}methyl)methylcarbamate (106 mg) in ethanol (2 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound (yield 44.3 mg, 48%).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-05d48bb61d33401085751fe8a3033f50
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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