Hydrogen chloride-ethyl acetate → HCID 67396620, compound

Participants

Reaction Steps

To a solution of tert-butyl {[1-[(3-cyanophenyl)sulfonyl]-5-(2-cyanopyridin-3-yl)-4-fluoro-1H-pyrrol-3-yl]methyl}methylcarbamate (401 mg) in ethyl acetate (3 mL) and 2-propanol (2 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (6 mL), and the mixture was stirred at room temperature for 17 hr. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from a mixed solvent of ethanol and water to give the title compound as a white solid (yield 276 mg, 79%).

Provenance & Evidence