Hydrogen chloride-ethyl acetate → HCID 67398608, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl {[1-(cyclohexylsulfonyl)-4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (420 mg) was dissolved in methanol (10 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (2 mL) was added, and the mixture was stirred at 70° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate to give the title compound as colorless crystals (yield 256 mg, 71%).

Provenance & Evidence