Dichloromethane → (+/-)-Pyrrolidine-3-carboxylic acid {4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenyl}-amide

HRID 142682Notes

Reaction equation

HRID 142682 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([C:13]([NH:14][c:15]2[cH:16][cH:17][c:18](-[n:21]3[c:22](=[O:37])[c:23]4[c:24]([cH:25][cH:26]3)[cH:27][c:28](-[c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[s:29]4)[cH:19][cH:20]2)=[O:38])[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:39][CH2:40][Cl:41]>>[NH:8]1[CH2:9][CH:10]([C:13]([NH:14][c:15]2[cH:16][cH:17][c:18](-[n:21]3[c:22](=[O:37])[c:23]4[c:24]([cH:25][cH:26]3)[cH:27][c:28](-[c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[s:29]4)[cH:19][cH:20]2)=[O:38])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 689499533-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86629215(+/-)-Pyrrolidine-3-carboxylic acid {4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenyl}-amide

Sources & evidence

ORD record
ord-8ad7de233d2540f08130c043e9222da3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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