Hydrogen chloride-ethyl acetate → HCID 69275718, compound

HRID 1426836Notes

Reaction equation

HRID 1426836 reaction equation
[F:1][CH:2]([F:34])[N:3]1[CH:7]=[C:6]([S:8]([N:11]2[C:15]([C:16]3[C:17]([F:22])=[N:18][CH:19]=[CH:20][CH:21]=3)=[C:14]([F:23])[C:13]([CH2:24][N:25](C)[C:26](=O)OC(C)(C)C)=[CH:12]2)(=[O:10])=[O:9])[CH:5]=[N:4]1.C(OCC)(=O)C.[ClH:41]>C(O)C>[ClH:41].[F:34][CH:2]([F:1])[N:3]1[CH:7]=[C:6]([S:8]([N:11]2[C:15]([C:16]3[C:17]([F:22])=[N:18][CH:19]=[CH:20][CH:21]=3)=[C:14]([F:23])[C:13]([CH2:24][NH:25][CH3:26])=[CH:12]2)(=[O:9])=[O:10])[CH:5]=[N:4]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67396227HCID 67396227, compound

Product 1

HCID 69275718HCID 69275718, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

tert-Butyl {[1-{[1-(difluoromethyl)-1H-pyrazol-4-yl]sulfonyl}-4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (380 mg) was dissolved in ethanol (10 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (10 mL) was added, and the mixture was stirred at 40° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate to give the title compound as colorless crystals (yield 240 mg, 72%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-3e0a203c3f4b43d2b7b8333d3f503ae3
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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