Hydrogen chloride-ethyl acetate → HCID 67395927, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(4-hydroxyphenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate (300 mg) was dissolved in ethanol (5 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (5 mL) was added, and the mixture was stirred at 40° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate, and further recrystallized from a mixed solvent of ethyl acetate-methanol (4:1) to give the title compound as colorless crystals (yield 208 mg, 81%).

Provenance & Evidence