HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6R)-9-fluoro-13,16-dioxa-2,11,20,21,24-pentazapentacyclo[16.5.2.02,6.07,12.021,25]pentacosa-1(24),7(12),8,10,18(25),19,22-heptaen-17-one → (6R)-9-fluoro-14-oxa-2,11,18,19,22-pentazapentacyclo[14.5.2.17,11.02,6.019,23]tetracosa-1(22),7,9,16(23),17,20-hexaene-15,24-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6R)-9-fluoro-13,16-dioxa-2,11,20,21,24-pentazapentacyclo[16.5.2.02,6.07,12.021,25]pentacosa-1(24),7(12),8,10,18(25),19,22-heptaen-17-one | HCID 70168413 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | (6R)-9-fluoro-14-oxa-2,11,18,19,22-pentazapentacyclo[14.5.2.17,11.02,6.019,23]tetracosa-1(22),7,9,16(23),17,20-hexaene-15,24-dione | HCID 70169716 | 9% |
Reaction Steps
Obtained as a by-product of Example 14, Step C, and isolated as a white solid (5 mg, 9% yield) by reverse phase column chromatography (Biotage SP4 system C-18 25+M column, 5 to 60% acetonitrile/water) of the crude material of Example 14, Step C. MS (apci) m/z=370.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933084B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-e845aeb7e3164ade9b0ba12c4c9fe881 |
| Source note | uspto-grants-2015_01 |