Carbon Tetrachloride → HCID 70168482, compound

Participants

Reaction Steps

A mixture of (R)-(5-(2-(2-(3-aminoprop oxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methanol (50 mg, 0.130 mmol), PS—PPh3 (0.259 mmol) and perchloromethane (200 mg, 1.30 mmol) in DCM (5 mL) was shaken at ambient temperature overnight. The reaction was filtered, concentrated and purified by reverse-phase column chromatography eluting with 0-60% acetonitrile/H2O to yield the title product (27.4 mg, 57.5% yield). MS (apci) m/z=368.1 (M+H).

Provenance & Evidence