Nitromethane → HCID 86730321, compound

Participants

Reaction Conditions

Reaction Steps

3-(Benzyloxy)-4-isopropoxybenzaldehyde described in Production Example 17-2 (2.59 g, 9.59 mmol) was dissolved in acetic acid (7.5 mL), then ammonium acetate (887 mg, 11.5 mmol) and nitromethane (1.25 mL, 23.1 mmol) were added under nitrogen atmosphere at room temperature, and the mixture was heated and stirred at 130° C. for 2 hours. The mixture was cooled to room temperature, and the precipitate was collected by filteration and washed with ethanol to obtain the title compound (2.20 g, 73%).

Provenance & Evidence