2-(6-Bromopyridin-2-yl)ethanol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 142712Notes

Reaction equation

HRID 142712 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH2:8][CH2:9][OH:10])[n:7]1.[NH2:11][c:12]1[s:13][c:14](-[c:20]2[c:21]([F:31])[cH:22][c:23]([C:27]([CH3:28])([CH3:29])[OH:30])[cH:24][c:25]2[F:26])[cH:15][c:16]1[C:17](=[O:18])[NH2:19]>>[c:2]1([NH:11][c:12]2[s:13][c:14](-[c:20]3[c:21]([F:31])[cH:22][c:23]([C:27]([CH3:28])([CH3:29])[OH:30])[cH:24][c:25]3[F:26])[cH:15][c:16]2[C:17](=[O:18])[NH2:19])[cH:3][cH:4][cH:5][c:6]([CH2:8][CH2:9][OH:10])[n:7]1

Participants

3

Reactant 2

HCID 468357132-(6-Bromopyridin-2-yl)ethanolHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595259405-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-e3247e2fb82648ca978b37e172211fcc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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