7-Methoxy-3,4-dihydrobenzo[f][1,4]thiazepin-5(2H)-one → 7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

Participants

Reaction Steps

7-Methoxy-5-oxo-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.300 g) was treated with LiAlH4 (0.160 g) in THF (10 ml) at reflux overnight. The mixture was cooled to room temperature and Na2SO4.10H2O was added slowly to quench the reaction. The resulting mixture was stirred at room temperature for 1 hour and filtered through a short celite column. Removal of the solvents led to the desired product as a colorless oil.

Provenance & Evidence