反应详情

温度

100 °C

To a solution of methyl 4-chloro-3-pyridinecarboxylate (1200 mg; may be prepared as described in Intermediate 18) and 2-(tributylstannanyl)pyrazine (3000 mg) in toluene (20 mL), tetrakis(triphenylphosphine)palladium(0) (808 mg) in toluene (20 mL) was added and the reaction mixture was stirred at 100° C. for 3 h. Then the solvent was evaporated in vacuo and the crude product was added to a silica gel column and eluted with cyclohexane/EtOAc/MeOH=7/2.5/0.5. The evaporation of the collected fractions gave 1 g of the title compound as a white solid.

1. customThen the solvent was evaporated in vacuo
2. additionthe crude product was added to a silica gel column
3. washeluted with cyclohexane/EtOAc/MeOH=7/2.5/0.5
4. customThe evaporation of the collected fractions