Diisopropylethylamine → HCID 70557764, Verbindung

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 1,3,4,10b-tetrahydropyrido[4′,3′:3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one (may be prepared as in Intermediate 22, 90 mg) in dichloromethane (15 mL) was added DIPEA (0.415 mL). This was cooled in an ice bath and to this was added 2-bromo-4-(trifluoromethyl)benzenesulfonyl chloride (162 mg). The mixture was stirred at room temperature overnight. The reaction mixture was washed with aqueous saturated sodium bicarbonate solution in a hydrophobic frit and then re-extracted with DCM. The combined organic phases were evaporated to give the title compound as a yellow oil which was used in the next reaction (263 mg).

Herkunft & Nachweise