HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1427161Generated: November 1, 2026
Diisopropylethylamine → 9-{[2-Bromo-4-(trifluoromethyl)phenyl]sulfonyl}-8,9,10,10a-tetrahydropyrido[2',3':3,4]pyrrolo[1,2-a]pyrazin-5(7H)-one
https://huagongshe.com/reaction/1427161
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromo-4-(trifluoromethyl)benzenesulfonyl chloride | HCID 2778611 | — |
| Reactant | HCID 70557780 | HCID 70557780 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 9-{[2-Bromo-4-(trifluoromethyl)phenyl]sulfonyl}-8,9,10,10a-tetrahydropyrido[2',3':3,4]pyrrolo[1,2-a]pyrazin-5(7H)-one | HCID 70558248 | — |
Reaction Steps
To a solution of 8,9,10,10a-tetrahydropyrido[2′,3′:3,4]pyrrolo[1,2-a]pyrazin-5(7H)-one (may be prepared as in Intermediate 7, 130 mg) in DCM (5 mL) was added DIPEA (0.360 mL, 2.061 mmol). The mixture was cooled to 0° C. and 2-bromo-4-(trifluoromethyl)benzenesulfonyl chloride (233 mg) was added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08933132B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-0e86cf92b78a4d94b7e8bcdde6112359 |
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| Source note | uspto-grants-2015_01 |
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