HCID 57524526, compound → 1H-Indole-1-acetic acid, 4-amino-α-(4-chlorophenyl)-, methyl ester

Participants

Reaction Steps

A solution of 1 (8.28 g, 24.0 mmol) in ethyl acetate (240 mL) was degassed, at which point platinum on carbon (1.41 g of a 10% wt/wt mixture, 0.721 mmol) was added, and the resulting suspension was stirred under a hydrogen atmosphere (balloon). After 3 h, the reaction mixture was filtered through a short column of CELITE® eluting with EtOAc. The combined organics were concentrated in vacuo to afford the title compound 2a. m/z (ES) 315 (MH)+.

Provenance & Evidence