反应详情

A solution of N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide (560 mg, 1.07 mmol) in DCM (10 mL) was added to Dess-Martin periodinane (590 mg, 1.39 mmol) in portion at 0° C. and stirred for 1.5 h. The mixture was diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and evaporated. The residue was purified by silica gel chromatography (PE/EA=8/1) to afford the title compound as a yellow solid. LC/MS m/z=522.1 [M+H]+.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by silica gel chromatography (PE/EA=8/1)