HCID 70564244, compound → HCID 70565327, compound

HRID 1427239Notes

Reaction equation

HRID 1427239 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:14]2[C:22]3[C:17](=[C:18]([NH:23]S(C)(=O)=O)[CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)([CH2:12][CH3:13])[CH2:9][C:10]#[N:11])=[CH:4][CH:3]=1>Cl.CO>[NH2:23][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:17]=1[CH:16]=[CH:15][N:14]2[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)([CH2:12][CH3:13])[CH2:9][C:10]#[N:11]

Participants

3

Reactant 1

HCID 70564244HCID 70564244, compound

Product 1

HCID 70565327HCID 70565327, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

The mixture of the product from Step C (250 mg, 0.59 mmol) and 4 N HCl/MeOH (10 mL) was stirred at room temperature for 2 h. After solvent was removed in vacuo, the residue was dissolved in ethyl acetate (20 mL), pH value adjusted to 9˜10 with a saturated sodium bicarbonate solution, dried over sodium sulfate, then filtered. After removing the organic solvent, the title compound as a colorless oil was obtained. LC/MS m/z=324.1 [M+H]+.

Workup

  1. customAfter solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ethyl acetate (20 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customAfter removing the organic solvent

Sources & evidence

ORD record
ord-815ee7e4c9744d50a60a18b7ac0931b0
Source dataset
uspto-grants-2015_01
Patent number
US08933113B2

Reaction notes

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