Iodoethane → HCID 70562623, compound

Participants

Reaction Steps

A solution of tert-butyl 1-(1-(4-chlorophenyl)-1-(2H-1,2,3-triazol-4-yl)propyl)-1H-indol-4-ylcarbamate (150 mg, 0.33 mmol) in DMF (5 mL), was added potassium carbonate (91 mg, 0.66 mmol) and iodoethane (62 mg, 0.40 mmol). After stirring for 2 hours, the mixture was diluted with saturated aqueous ammonium chloride (10 mL) and extracted with EA. The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, filtered, and the solvent was removed in vacuo to afford the crude product. The product was purified via column chromatography (50% EtOAc/hexanes) to provide the title product.

Provenance & Evidence