HCID 70564665, compound → HCID 70563939, compound

HRID 1427262Notes

Reaction equation

HRID 1427262 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:15]2[C:23]3[C:18](=[C:19]([NH:24]C(=O)OC(C)(C)C)[CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16]2)([C:11]2([OH:14])[CH2:13][CH2:12]2)[CH2:9][CH3:10])=[CH:4][CH:3]=1>Cl.CO>[NH2:24][C:19]1[CH:20]=[CH:21][CH:22]=[C:23]2[C:18]=1[CH:17]=[CH:16][N:15]2[C:8]([C:11]1([OH:14])[CH2:12][CH2:13]1)([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:9][CH3:10]

Participants

3

Reactant 1

HCID 70564665HCID 70564665, compound

Product 1

HCID 70563939HCID 70563939, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

Compound from step A (96 mg, 0.22 mmol) was treated with 10 mL 4N HCl/MeOH solution over night. The solvents were removed by reduced pressure to give white product. LC/MS m/z=341.0[M+H]+.

Workup

  1. customThe solvents were removed by reduced pressure
  2. customto give white product

Sources & evidence

ORD record
ord-96ed041c175641dfab5f58127739339c
Source dataset
uspto-grants-2015_01
Patent number
US08933113B2

Reaction notes

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