HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 86705052, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86705051 | HCID 86705051 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86705052 | HCID 86705052 | — |
Reaction Steps
To a solution of the product from step B (40 mg, 0.071 mmol, enantiomer A) in DMF (5 mL) was added DIPEA (18 mg, 0.142 mmol), HATU (40 mg, 0.11 mmol), NH4Cl (38 mg, 0.71 mmol). The mixture was stirred at RT overnight. After removing the organic solvent, the residue was dissolved with H2O (20 mL), extracted with ethyl acetate, and washed with brine, dried over sodium sulfate, then filtered. The solvent was evaporated and the residue was purified by Prep-TLC (EA/PE=2:1) to obtain the title compound. LC/MS m/z=582.0 [M+Na]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933113B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ab268847b7bb40f297ba9d85f1b48fd4 |
| Source note | uspto-grants-2015_01 |