反应详情

To a solution of the product of Step C (1.2 g, 2.4 mmol) in DCM (10 mL) was added Dess-Martin periodinane (2.03 g, 4.8 mmol) in portion at room temperature. After stirring for 0.5 h, the mixture was diluted with water (15 mL), extracted with ethyl acetate. The organic layers were washed with brine (10 mL), dried over sodium sulfate, filtered and evaporated. The residue was purified by silica gel chromatography (EA/PE=1:8) to afford the title compound. LC/MS m/z=499.2[M+H]+.

1. extractionextracted with ethyl acetate
2. washThe organic layers were washed with brine (10 mL)
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by silica gel chromatography (EA/PE=1:8)