2-Chloro-4-fluorophenacyl bromide → 5-(2-Chloro-4-fluorophenyl)-7-methyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine

HRID 1427372Notes

Reaction equation

HRID 1427372 reaction equation
FC1C=CC=CC=1C1[N:9]=[C:10]([CH3:22])[N:11]2C=1[C:15]([N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[N:14][CH:13]=[N:12]2.Br[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=1[Cl:34])=O>>[Cl:34][C:28]1[CH:29]=[C:30]([F:33])[CH:31]=[CH:32][C:27]=1[C:25]1[N:9]=[C:10]([CH3:22])[N:11]2[C:24]=1[C:15]([N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[N:14][CH:13]=[N:12]2

Participants

3

Reactant 2

HCID 125933352-Chloro-4-fluorophenacyl bromideHCID 1176784165-(2-fluorophenyl)-7-methyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine

Product 1

HCID 1176784295-(2-Chloro-4-fluorophenyl)-7-methyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine

Procedure

5-(2-Chloro-4-fluorophenyl)-7-methyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine was prepared in similar fashion to C6 in Example 1, by employing 2-bromo-1-(2-chloro-4-fluorophenyl)ethanone.

Sources & evidence

ORD record
ord-cc08f20a3cd644dc9d239c0334c2c3e4
Source dataset
uspto-grants-2015_01
Patent number
US08933224B2

Reaction notes

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