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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1427376Generated: November 2, 2026

1,1,1-Trifluoro-2-iodoethane → 1-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

https://huagongshe.com/reaction/1427376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1,1-Trifluoro-2-iodoethaneHCID 67709—
Reactant1H-Pyrazolo[3,4-c]pyridineHCID 6451441—
CatalystAdams' catalystHCID 345198—
Product1-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridineHCID 117678384—

Reaction Steps

1H-Pyrazolo[3,4-c]pyridine was alkylated with 1,1,1-trifluoro-2-iodoethane, then reduced via hydrogenation over platinum(IV) oxide to afford 1-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08933224B2
Source datasetuspto-grants-2015_01
ORD IDord-c85c9c97d3324451a59b2daa331b0f19
Source noteuspto-grants-2015_01