HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1427677Generated: November 1, 2026
Nitromethane → 3-hydroxy-3-(nitromethyl)-1,3-dihydro-2H-indol-2-one
https://huagongshe.com/reaction/1427677
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Isatin | HCID 7054 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-hydroxy-3-(nitromethyl)-1,3-dihydro-2H-indol-2-one | HCID 225464 | — |
Reaction Steps
Isatin (0.073 g) and nitromethane (0.1 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 10 minutes. The formed solid product was filtered and recrystallized with MeOH to afford pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08933248B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-3c15383957f3429990f890839192e580 |
|---|
| Source note | uspto-grants-2015_01 |
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