Nitromethane → 3-Hydroxy-7-iodo-3-(nitromethyl)indolin-2-one

Participants

Reaction Conditions

Reaction Steps

7-iodoisatin (0.136 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Provenance & Evidence