Nitromethane → 1,3-Dihydro-3-hydroxy-1-methyl-3-(nitromethyl)-2H-indol-2-one

Participants

Reaction Conditions

Reaction Steps

N-methyl isatin (0.08 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Provenance & Evidence