1,2-Dichloroethane → HCID 86295409, compound

Participants

Reaction Steps

N-hydroxysuccinimide (252 mg, 2.30 mmol) was added to a solution of 1-((4-(4-(3-(3-(prop-2-yn-1-yloxy)propanamido)propoxy)benzoyl)phenyl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid (1.25 g, 1.98 mmol) in anhydrous DCM (10 ml) was added followed by EDC (505 mg, 2.64 mmol). The reaction was stirred at r.t. for 2-3 hs. Upon completion, reaction was concentrated under reduced pressure and purified by silica gel chromatography (DCM to DCM:iPrOH gradient) to provide 1.16 g (1.63 mmol, 80% yield) of 2,5-dioxopyrrolidin-1-yl 1-((4-(4-(3-(3-(prop-2-yn-1-yloxy)propanamido)propoxy)benzoyl)phenyl)amino)-3,6,9,12-tetraoxapentadecan-15-oate as slightly yellow oil.

Provenance & Evidence