Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → HCID 72948340, compound

Participants

Reaction Steps

Following the procedure as described in Example 8 and making variations as required to replace 5-chloro-2,4-difluoro-N-(methylsulfonyl)benzamide with 5-chloro-N—(N,N-dimethylsulfamoyl)-2,4-difluorobenzamide and adamantan-1-ylmethanol with 2-(4-methoxyphenyl)ethanol, the title compound was obtained as a colorless solid (0.17 g, 39%): 1H NMR (300 MHz, DMSO-d6) δ 11.75 (s, 1H), 7.72 (d, J=7.4 Hz, 1H), 7.29-7.23 (m, 3H), 6.90-6.85 (m, 2H), 4.30 (t, J=6.8 Hz, 2H), 3.72 (s, 3H), 3.01 (t, J=6.8 Hz, 2H), 2.87 (s, 6H); MS (ES−) m/z 429.2, 431.2 (M−1).

Provenance & Evidence