HCID 59463822, compound → HCID 59463820, compound

HRID 1427989Notes

Reaction equation

HRID 1427989 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([C:17]3[C:21]([CH3:22])=[CH:20][S:19][CH:18]=3)[CH:9]=2)[CH2:4][CH2:3]1>[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[C:10]([C:17]3[C:21]([CH3:22])=[CH:20][S:19][CH:18]=3)[CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 59463822HCID 59463822, compound

Product 1

HCID 59463820HCID 59463820, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using a procedure similar to Example 4, step (d), 1-methyl-4-[3-(4-methyl-thiophen-3-yl)-4-nitro-phenyl]-piperazine (100 mg, 0.32 mmol) was stirred with 80 mg 5% Pd—C under H2 to afford 82 mg (89%) of the title compound as a dark oil, which was used immediately without further purification spectrum (ESI, m/z): Calcd. for C16H21N3S, 288.15 (M+H). found 288.1.

Sources & evidence

ORD record
ord-35b0295a874849e5871c9e38d85782e9
Source dataset
uspto-grants-2015_01
Patent number
US08933091B2

Reaction notes

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